Analysis of Glycosaminoglycans Using Mass Spectrometry
نویسندگان
چکیده
منابع مشابه
Compositional analysis of glycosaminoglycans by electrospray mass spectrometry.
The purpose of this work is to analyze glycosaminoglycans (GAGs) directly from complex mixtures without the need to purify individual components. Novel conditions for negative ion electrospray MS of chondroitin sulfate (CS) oligosaccharides are described in which sodium adduction and fragmentation are avoided. Differentiation between positional sulfation isomers is demonstrated for CS disacchar...
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Glycosaminoglycans (GAGs) are distributed in the whole body and play a variety of important physiological roles associated with inflammation, growth, coagulation, fibrinolysis, lipolysis, and cell-matrix biology. Accumulation of undegraded GAGs in lysosomes gives rise to a distinct clinical syndrome, mucopolysaccharidoses. Measurement of each specific GAG in a variety of specimens is urgently r...
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ژورنال
عنوان ژورنال: Current Proteomics
سال: 2011
ISSN: 1570-1646
DOI: 10.2174/157016411798220871